The Shrestha Lab is a computational cancer genomics and data science research group at the Center for Prostate Disease Research (CPDR). We focus on elucidating the drivers of cancer progression and therapeutic resistance, with the goal of advancing personalized medicine and improving clinical outcomes for prostate cancer patients by understanding the complex interplay of the genome, transcriptome, proteome, and epigenome.

Algorithm Development: Develop cutting-edge computational genomics and machine learning methods to unravel the complexities of cancer
Data Mining & Analytics: Mine, Integrate & Analyze complex multi-modal biological datasets to understand context-specific genome regulation in cancer
Translational Bioinformatics: Translate genomic insights to meaningful clinical applications for precision oncology
We are located at the Center for Prostate Disease Research (CPDR) under the Henry M Jackson Foundation for the Advancement of Military Medicine (HJF) in Bethesda, Maryland. Our lab is a part of Murtha Cancer Center Reseaerch Program (MCCRP) and Walter Reed National Military Medical Center (WRNMMC).
Academically, we are primarily affiliated with the Uniformed Services University of the Health Sciences (USUHS), Dept. of Surgery, with a secondary affiliation at the Genitourinary Malignancies Branch (GMB), National Cancer Institute (NCI).